Maternal Vascular Lesions in the Placenta Predict Vascular Impairments a Decade After Delivery.

ABSTRACT: Women with adverse pregnancy outcomes later experience excess hypertension and cardiovascular disease, but how the events are linked is unknown. Examination of the placenta may provide clues to vascular impairments after delivery. Maternal vascular malperfusion lesions (MVMs) were abstracted from clinical reports, validated and characterized using clinical guidelines and severity score. A total of 492 women (170 with MVMs and 322 without MVMs) participated in a study visit 8 to 10 years after delivery to assess blood pressure, cardiometabolic factors, and sublingual microvascular features using sidestream dark field imaging. Covariates included age, race, adverse pregnancy outcomes (preeclampsia, small for gestational age, and preterm birth), and health behaviors. Women with versus without

SUBMITTER: Catov JM 

PROVIDER: S-EPMC9026545 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature