CD10 and Das1: a biomarker study using immunohistochemistry to subtype gastric intestinal metaplasia.

ABSTRACT:

Background

Intestinal metaplasia (IM) is considered a key pivot point in the Correa model of gastric cancer (GC). It is histologically subtyped into the complete and incomplete subtypes, the latter being associated with a greater risk of progression. However, the clinical utility of IM subtyping remains unclear, partially due to the absence of reliable defining biomarkers.

Methods

Based on gene expression data and existing literature, we selected CD10 and Das1 as candidate biomarkers to distinguish complete and incomplete IM glands in tissues from patients without GC (IM-GC) and patients with GC (IM + GC). Immunohistochemical staining of individually subtyped IM glands was scored after blinding by two researchers using tissue belonging to both IM-GC and IM + GC patients. Who

SUBMITTER: Koulis A 

PROVIDER: S-EPMC9026694 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature