Plasma Metabolic and Lipidomic Fingerprinting of Individuals with Increased Intestinal Permeability.

ABSTRACT: The dual-sugar intestinal permeability test is a commonly used test to assess changes in gut barrier function. However, it does not identify functional changes and the exact mechanism of damage caused by the increased intestinal permeability. This study aims to explore the application of untargeted metabolomics and lipidomics to identify markers of increased intestinal permeability. Fifty fasting male participants (18-50 years) attended a single visit to conduct the following procedures: assessment of anthropometric measures, assessment of gastrointestinal symptoms, intestinal permeability test, and assessment of blood samples 90 min post-administration of the intestinal permeability test. Rhamnose and lactulose were analysed using gas chromatography-mass spectrometry (GC-MS). Untargeted p

SUBMITTER: Shah RM 

PROVIDER: S-EPMC9026773 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature