Deciphering HER2-HER3 Dimerization at the Single CTC Level: A Microfluidic Approach.

ABSTRACT: Microfluidics has provided clinicians with new technologies to detect and analyze circulating tumor biomarkers in order to further improve their understanding of disease mechanism, as well as to improve patient management. Among these different biomarkers, circulating tumor cells have proven to be of high interest for different types of cancer and in particular for breast cancer. Here we focus our attention on a breast cancer subtype referred as HER2-positive breast cancer, this cancer being associated with an amplification of HER2 protein at the plasma membrane of cancer cells. Combined with therapies targeting the HER2 protein, HER2-HER3 dimerization blockade further improves a patient's outcome. In this work, we propose a new approach to CTC characterization by on-chip integrating proxi

SUBMITTER: Tulukcuoglu Guneri E 

PROVIDER: S-EPMC9026778 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature