Antifungal Activity and Stability of Fluconazole Emulsion Containing Ionic Liquids Explained by Intermolecular Interactions.

ABSTRACT: This research reports accelerated stability experiments, the evaluation of intermolecular interactions, and antifungal assays for fluconazole emulsions prepared using ultrasound (US) and magnetic stirring (MS) in the presence of ionic liquids derived from 1,n-(3-methylimidazolium-1-yl)alkane bromide ([C_nMIM]Br; n = 12 or 16). The goals of the investigation are to quantify the stability, identify the forces that drive the formation and stability, and determine the antifungal activity of fluconazole-containing emulsions, and corroborate the data from our previous results that indicated that the emulsion based on [C₁₆MIM]Br seemed to be more stable. In this study, accelerated stability experiments evidenced a considerable stability for the [C₁₆MI

SUBMITTER: Hennemann BL 

PROVIDER: S-EPMC9026797 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature