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Mechanochemical Dimerization of Aldoximes to Furoxans.

ABSTRACT: Solvent-free mechanical milling is a new, environmentally friendly and cost-effective technology that is now widely used in the field of organic synthesis. The mechanochemical solvent-free synthesis of furoxans from aldoximes was achieved through dimerization of the in situ generated nitrile oxides in the presence of sodium chloride, Oxone and a base. A variety of furoxans was obtained with up to a 92% yield. The present protocol has the advantages of high reaction efficiency and mild reaction conditions.

SUBMITTER: Fang RK

PROVIDER: S-EPMC9027020 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature

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Mechanochemical Dimerization of Aldoximes to Furoxans.

Fang Run-Kai RK Chen Kuan K Niu Chuang C Wang Guan-Wu GW

Molecules (Basel, Switzerland) 20220418 8

Solvent-free mechanical milling is a new, environmentally friendly and cost-effective technology that is now widely used in the field of organic synthesis. The mechanochemical solvent-free synthesis of furoxans from aldoximes was achieved through dimerization of the in situ generated nitrile oxides in the presence of sodium chloride, Oxone and a base. A variety of furoxans was obtained with up to a 92% yield. The present protocol has the advantages of high reaction efficiency and mild reaction c ...[more]

PMID: 35458802

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