Prohemocytes are the main cells infected by dengue virus in Aedes aegypti and Aedes albopictus.

ABSTRACT:

Background

The primary disease vectors for dengue virus (DENV) transmission between humans are the mosquitoes Aedes aegypti and Aedes albopictus, with Ae. aegypti population size strongly correlated with DENV outbreaks. When a mosquito is infected with DENV, the virus migrates from the midgut to the salivary glands to complete the transmission cycle. How the virus crosses the hemocoel, resulting in systemic infection, is still unclear however. During viral infection and migration, the innate immune system is activated in defense. As part of cellular-mediated immunity, hemocytes are known to defend against bacteria and Plasmodium infection and may also participate in defending against DENV infection. Hemocytes are categorized into three cell types: prohemocytes, granulocytes, and oe

SUBMITTER: Cheng L 

PROVIDER: S-EPMC9027048 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature