CDK16 promotes the progression and metastasis of triple-negative breast cancer by phosphorylating PRC1.

ABSTRACT:

Background

Cyclin-dependent kinase 16 (CDK16) is an atypical PCTAIRE kinase, and its activity is dependent on the Cyclin Y (CCNY) family. Ccnys have been reported to regulate mammary stem cell activity and mammary gland development, and CCNY has been recognized as an oncoprotein in various cancers, including breast cancer. However, it remains unclear whether CDK16 has a role in breast cancer and whether it can be used as a therapeutic target for breast cancer.

Methods

Publicly available breast cancer datasets analyses and Kaplan-Meier survival analyses were performed to reveal the expression and clinical relevance of atypical CDKs in breast cancer. CDK16 protein expression was further examined by immunohistochemical and immunoblot analyses of clinical samples. Cell prolifera

SUBMITTER: Li X 

PROVIDER: S-EPMC9027050 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature