Aortic Fibrosis in Insulin-Sensitive Mice with Endothelial Cell-Specific Deletion of Ceacam1 Gene.

ABSTRACT: (1) Background: Mice with global Ceacam1 deletion developed plaque-like aortic lesions even on C57BL/6J background in the presence of increased endothelial cell permeability and insulin resistance. Loss of endothelial Ceacam1 gene caused endothelial dysfunction and reduced vascular integrity without affecting systemic insulin sensitivity. Because endothelial cell injury precedes atherosclerosis, we herein investigated whether the loss of endothelial Ceacam1 initiates atheroma formation in the absence of insulin resistance. (2) Methods: Endothelial cell-specific Ceacam1 null mice on C57BL/6J.Ldlr^-/- background (Ldlr^-/-VECadCre+Cc1^fl/fl) were fed an atherogenic diet for 3-5 months before metabolic, histopathological,

SUBMITTER: Abu Helal R 

PROVIDER: S-EPMC9027102 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature