Which Actigraphy Dimensions Predict Longitudinal Outcomes in Bipolar Disorders?

ABSTRACT: Bipolar disorder (BD) is characterized by recurrent mood episodes. It is increasingly suggested that disturbances in sleep-wake cycles and/or circadian rhythms could represent valuable predictors of recurrence, but few studies have addressed this question. Euthymic individuals with BD (n = 69) undertook 3 weeks of actigraphy recording and were then followed up for a median duration of 3.5 years. Principal component analyses were used to identify core dimensions of sleep quantity/variability and circadian rhythmicity. Associations between clinical variables and actigraphy dimensions and time to first recurrence were explored using survival analyses, and then using area under the curve (AUC) analyses (early vs. late recurrence). Most participants (64%) experienced a recurrence during follow-

SUBMITTER: Ferrand L 

PROVIDER: S-EPMC9027161 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature