The Role of Fecal Microbiota Transplantation in the Treatment of Acute Graft-versus-Host Disease.

ABSTRACT: The number of allogeneic hematopoietic stem cell transplantations conducted worldwide is constantly rising. Together with that, the absolute number of complications after the procedure is increasing, with graft-versus-host disease (GvHD) being one of the most common. The standard treatment is steroid administration, but only 40-60% of patients will respond to the therapy and some others will be steroid-dependent. There is still no consensus regarding the best second-line option, but fecal microbiota transplantation (FMT) has shown encouraging preliminary and first clinically relevant results in recent years and seems to offer great hope for patients. The reason for treatment of steroid-resistant acute GvHD using this method derives from studies showing the significant immunomodulatory role

SUBMITTER: Bilinski J 

PROVIDER: S-EPMC9027325 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature