Gut Microbial Signatures of Distinct Trimethylamine N-Oxide Response to Raspberry Consumption.

ABSTRACT: The aim of this exploratory study was to evaluate the gut microbial signatures of distinct trimethylamine N-oxide (TMAO) responses following raspberry consumption. Investigations were carried out in 24 subjects at risk of developing metabolic syndrome who received 280 g/day of frozen raspberries for 8 weeks. Blood and stool samples were collected at weeks 0 and 8. Inter-individual variability in plasma TMAO levels was analyzed, 7 subjects were excluded due to noninformative signals and 17 subjects were kept for analysis and further stratified according to their TMAO response. Whole-metagenome shotgun sequencing analysis was used to determine the impact of raspberry consumption on gut microbial composition. Before the intervention, the relative abundance of Actinobacteriota was significantl

SUBMITTER: Franck M 

PROVIDER: S-EPMC9027468 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature