Circular RNA Profiles in Viremia and ART Suppression Predict Competing circRNA-miRNA-mRNA Networks Exclusive to HIV-1 Viremic Patients.

ABSTRACT: Since the onset of the HIV-1/AIDS epidemic in 1981, 75 million people have been infected with the virus, and the disease remains a public health crisis worldwide. Circular RNAs (circRNAs) are derived from excised exons and introns during backsplicing, a form of alternative splicing. The relevance of unconventional, non-capped, and non-poly(A) transcripts to transcriptomics studies remains to be routinely investigated. Knowledge gaps to be filled are the interface between host-encoded circRNAs and viral replication in chronically progressed patients and upon treatment with antiviral drugs. We implemented a bioinformatic pipeline and repurpose publicly archived RNA sequence reads from the blood of 19 HIV-1-positive patients that previously compared transcriptomes during viremia and viremia s

SUBMITTER: Zucko D 

PROVIDER: S-EPMC9027527 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature