Acute Kidney Function Declines in the Context of Decongestion in Acute Decompensated Heart Failure.

ABSTRACT:

Objectives

This study aimed to examine whether incorporation of a comprehensive set of measures of decongestion modifies the association of acute declines in kidney function with outcomes.

Background

In-hospital acute declines in kidney function occur in approximately 20% to 30% of patients admitted with acute decompensated heart failure (ADHF) and may be associated with adverse outcomes.

Methods

Using data from EVEREST (Efficacy of Vasopressin Antagonism in Heart Failure Outcome Study With Tolvaptan), we used multivariable Cox regression models to evaluate the association between in-hospital changes in estimated glomerular filtration rate (eGFR) with death and a composite outcome of cardiovascular death and hospitalization for heart failure. We evaluated eGFR decline

SUBMITTER: McCallum W 

PROVIDER: S-EPMC9027677 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature