Amyloid and Tau Protein Concentrations in Children with Meningitis and Encephalitis.

ABSTRACT: Alzheimer's disease (AD) has emerged as a growing threat to human health. It is a multifactorial disorder, in which abnormal amyloid beta metabolism and neuroinflammation have been demonstrated to play a key role. Intrathecal inflammation can be triggered by infections and precede brain damage for years. We analyzed the influence of infections of the central nervous system on biomarkers that are crucially involved in AD pathology. Analyses of the cerebrospinal fluid (CSF) levels of Aβ_1-42, Aβ_1-40, Tau, and pTau proteins were performed in 53 children with neuroinfections of viral (n = 26) and bacterial origin (n = 19), and in controls (n = 8). We found no changes in CSF amyloid Aβ_1-42 concentrations, regardless of etiology. We showed an

SUBMITTER: Sulik A 

PROVIDER: S-EPMC9027807 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature