Manipulating Reaction Energy Coordinate Landscape of Mechanochemical Diaza-Cope Rearrangement.

ABSTRACT: Chiral vicinal diamines, a unique class of optically-active building blocks, play a crucial role in material design, pharmaceutical, and catalysis. Traditionally, their syntheses are all solvent-based approaches, which make organic solvent an indispensable part of their production. As part of our program aiming to develop chemical processes with reduced carbon footprints, we recently reported a highly practical and environmentally-friendly synthetic route to chiral vicinal diamines by solvent-free mechanochemical diaza-Cope rearrangement. We herein showed that a new protocol by co-milling with common laboratory solid additives, such as silica gel, can significantly enhance the efficiency of the reaction, compared to reactions in the absence of additives. One possible explanation is the Lew

SUBMITTER: Cheng T 

PROVIDER: S-EPMC9027841 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature