The Evolution of the Satratoxin and Atranone Gene Clusters of Stachybotrys chartarum.

ABSTRACT: Stachybotrys chartarum is frequently isolated from damp building materials or improperly stored animal forage. Human and animal exposure to the secondary metabolites of this mold is linked to severe health effects. The mutually exclusive production of either satratoxins or atranones defines the chemotypes A and S. Based upon the genes (satratoxin cluster, SC1-3, sat or atranone cluster, AC1, atr) that are supposed to be essential for satratoxin and atranone production, S. chartarum can furthermore be divided into three genotypes: the S-type possessing all sat- but no atr-genes, the A-type lacking the sat- but harboring all atr-genes, and the H-type having only certain sat- and all atr-genes. We analyzed the above-mention

SUBMITTER: Ulrich S 

PROVIDER: S-EPMC9027890 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature