Carnosic Acid and Carnosol Display Antioxidant and Anti-Prion Properties in In Vitro and Cell-Free Models of Prion Diseases.

ABSTRACT: Prion diseases are transmissible encephalopathies associated with the conversion of the physiological form of the prion protein (PrP^C) to the disease-associated (PrP^Sc). Despite intense research, no therapeutic or prophylactic agent is available. The catechol-type diterpene Carnosic acid (CA) and its metabolite Carnosol (CS) from Rosmarinus officinalis have well-documented anti-oxidative and neuroprotective effects. Since oxidative stress plays an important role in the pathogenesis of prion diseases, we investigated the potential beneficial role of CA and CS in a cellular model of prion diseases (N2a22L cells) and in a cell-free prion amplification assay (RT-QuIC). The antioxidant effects of the compounds were confirmed when N2a22L were incubated with CA or CS. Furthe

SUBMITTER: Karagianni K 

PROVIDER: S-EPMC9027925 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature