The Genomic Profile Associated with Risk of Severe Forms of COVID-19 in Amazonian Native American Populations.

ABSTRACT: Genetic factors associated with COVID-19 disease outcomes are poorly understood. This study aimed to associate genetic variants in the SLC6A20, LZTFL1, CCR9, FYCO1, CXCR6, XCR1, and ABO genes with the risk of severe forms of COVID-19 in Amazonian Native Americans, and to compare the frequencies with continental populations. The study population was composed of 64 Amerindians from the Amazon region of northern Brazil. The difference in frequencies between the populations was analyzed using Fisher's exact test, and the results were significant when p ≤ 0.05. We investigated 64 polymorphisms in 7 genes; we studied 47 genetic variants that were new or had impact predictions of high, moderate, or modifier. We identified 15 polymorphisms wi

SUBMITTER: Pastana LF 

PROVIDER: S-EPMC9027999 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature