The Clinical Utility of D-Dimer and Prothrombin Fragment (F1+2) for Peripheral Artery Disease: A Prospective Study.

ABSTRACT: D-dimer and prothrombin fragment (F1+2) levels are elevated in patients with peripheral artery disease (PAD). We examined their prognostic potential in predicting decreasing ABI and major adverse limb events (MALE). A total of 206 patients were recruited from St. Michael's Hospital and followed for two years. Baseline plasma concentrations of D-dimer and F1+2 were recorded. Pearson's correlation was used to assess the correlation between the biomarkers and ABI at year 2. During follow-up, multivariable Cox proportional hazard analysis was performed to investigate their role in predicting decreasing ABI (defined as change in ABI > -0.15) and MALE (defined as the need for arterial intervention or major limb amputation). Cumulative survival was assessed using Kaplan-Meier analysis. Baselin

SUBMITTER: Arfan S 

PROVIDER: S-EPMC9028031 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature