Clinical Implications of Circulating Circular RNAs in Lung Cancer.

ABSTRACT: Circular RNAs (circRNAs) are single-stranded RNAs with a covalently closed-loop structure that increases their stability; thus, they are more advantageous to use as liquid biopsy markers than linear RNAs. circRNAs are thought to be generated by back-splicing of pre-mRNA transcripts, which can be facilitated by reverse complementary sequences in the flanking introns and trans-acting factors, such as splicing regulatory factors and RNA-binding factors. circRNAs function as miRNA sponges, interact with target proteins, regulate the stability and translatability of other mRNAs, regulate gene expression, and produce microproteins. circRNAs are also found in the body fluids of cancer patients, including plasma, saliva, urine, and cerebrospinal fluid, and these "circulating circRNAs" can be used

SUBMITTER: Choi SS 

PROVIDER: S-EPMC9028053 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature