Ontology highlight
ABSTRACT:
SUBMITTER: Garciaz S
PROVIDER: S-EPMC9028084 | biostudies-literature | 2022 Apr
REPOSITORIES: biostudies-literature
Garciaz Sylvain S Hospital Marie-Anne MA Alary Anne-Sophie AS Saillard Colombe C Hicheri Yosr Y Mohty Bilal B Rey Jérôme J D'Incan Evelyne E Charbonnier Aude A Villetard Ferdinand F Maisano Valerio V Lombardi Laura L Ittel Antoine A Mozziconacci Marie-Joelle MJ Gelsi-Boyer Véronique V Vey Norbert N
Cancers 20220416 8
Venetoclax (VEN) belongs the BH3-mimetic class that selectively targets BCL-2, activating apoptosis. The combination of VEN and azacitidine (AZA) has changed the paradigm of treatment of newly diagnosed (ND) acute myeloid leukemia (AML) patients ineligible for intensive chemotherapy. There is scarce evidence for the use of VEN-AZA for relapsed or refractory (R/R) AML. We compared the outcome of 39 R/R AML and 38 ND AML patients treated between 01/20 and 12/21. The median age was 69 (22-86) and 7 ...[more]