Profiling the lncRNA-miRNA-mRNA interaction network in the submandibular gland of diabetic mice.

ABSTRACT:

Background

Hyposalivation is one of the common symptoms of diabetes. Although long non-coding RNAs (lncRNAs) have recently been reported to play important roles in the pathogenesis of diabetes, the role of lncRNAs in diabetes-induced hyposalivation remains unknown.

Methods

The present study aimed to explore the function of lncRNA-microRNA-mRNA regulatory network in the submandibular gland (SMGs) under the context of diabetes. LncRNA expression profile of the SMGs was analyzed using microarray technology. Differentially expressed lncRNAs were confirmed using real-time quantitative PCR. Bioinformatics analyses were performed, and Coding-non-coding gene co-expression (CNC) and competing endogenous RNA (ceRNA) networks were constructed to explore the potential mechanisms of diab

SUBMITTER: Shi XJ 

PROVIDER: S-EPMC9028094 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature