Microbowls with Controlled Concavity for Accurate Microscale Mass Spectrometry.
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ABSTRACT:
SUBMITTER: Xu L
PROVIDER: S-EPMC9028217 | biostudies-literature | 2022 Mar
REPOSITORIES: biostudies-literature
Publications
Microbowls with Controlled Concavity for Accurate Microscale Mass Spectrometry.
Xu Linfeng L Li Xiangpeng X Li Wenzong W Chang Kai-Chun KC Yang Hyunjun H Tao Nannan N Zhang Pengfei P Payne Emory M EM Modavi Cyrus C Humphries Jacqueline J Lu Chia-Wei CW Abate Adam R AR
Advanced materials (Deerfield Beach, Fla.) 20220210 12
Patterned surfaces can enhance the sensitivity of laser desorption ionization mass spectrometry by segregating and concentrating analytes, but their fabrication can be challenging. Here, a simple method to fabricate substrates patterned with micrometer-scale wells that yield more accurate and sensitive mass spectrometry measurements compared to flat surfaces is described. The wells can also concentrate and localize cells and beads for cell-based assays. ...[more]
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