Microbowls with Controlled Concavity for Accurate Microscale Mass Spectrometry.

ABSTRACT: Patterned surfaces can enhance the sensitivity of laser desorption ionization mass spectrometry by segregating and concentrating analytes, but their fabrication can be challenging. Here, a simple method to fabricate substrates patterned with micrometer-scale wells that yield more accurate and sensitive mass spectrometry measurements compared to flat surfaces is described. The wells can also concentrate and localize cells and beads for cell-based assays.

SUBMITTER: Xu L 

PROVIDER: S-EPMC9028217 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature