MR-Guided Adaptive Radiotherapy for OAR Sparing in Head and Neck Cancers.

ABSTRACT: MR-linac devices offer the potential for advancements in radiotherapy (RT) treatment of head and neck cancer (HNC) by using daily MR imaging performed at the time and setup of treatment delivery. This article aims to present a review of current adaptive RT (ART) methods on MR-Linac devices directed towards the sparing of organs at risk (OAR) and a view of future adaptive techniques seeking to improve the therapeutic ratio. This ratio expresses the relationship between the probability of tumor control and the probability of normal tissue damage and is thus an important conceptual metric of success in the sparing of OARs. Increasing spatial conformity of dose distributions to target volume and OARs is an initial step in achieving therapeutic improvements, followed by the use of imaging and c

SUBMITTER: Mulder SL 

PROVIDER: S-EPMC9028510 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature