Pharmacovigilance in Pediatric Patients with Epilepsy Using Antiepileptic Drugs.

ABSTRACT:

Objective

To investigate the occurrence of adverse effects of antiepileptic drugs (AEDs) in pediatric epileptic patients on mono- or polytherapy.

Method

We evaluated eighty consecutive patients that met the following inclusion criteria: aged ≤18 years; diagnosed with epilepsy for at least one year; a stable dose of AED for at least three months; verbal consent to participation in the study. Patients were asked if they had experienced any adverse drug reaction (ADR) related to the AED. Afterward, regardless of the answer, they were interviewed based on a detailed semi-structured questionnaire about the presence of ADRs associated with the AED. The data were analyzed regarding the use of monotherapy or polytherapy.

Results

Ninety-seven percent of the patients reported h

SUBMITTER: Kopciuch D 

PROVIDER: S-EPMC9028571 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature