Alzheimer's Disease Variant Portal: A Catalog of Genetic Findings for Alzheimer's Disease.

ABSTRACT:

Background

Recent Alzheimer's disease (AD) genetics findings from genome-wide association studies (GWAS) span progressively larger and more diverse populations and outcomes. Currently, there is no up-to-date resource providing harmonized and searchable information on all AD genetic associations found by GWAS, nor linking the reported genetic variants and genes with functional and genomic annotations.

Objective

Create an integrated/harmonized, and literature-derived collection of population-specific AD genetic associations.

Methods

We developed the Alzheimer's Disease Variant Portal (ADVP), an extensive collection of associations curated from >200 GWAS publications from Alzheimer's Disease Genetics Consortium and other consortia. Genetic associations were systematicall

SUBMITTER: Kuksa PP 

PROVIDER: S-EPMC9028687 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature