The Relationship between Alcohol Consumption and Gout: A Mendelian Randomization Study.

ABSTRACT: Gout is a disease that manifests itself after decades of following a high-purine diet, with excessive alcohol consumption assumed to be one of the main contributors to the development of the disease. This study performs a Mendelian randomization (MR) analysis to determine whether alcohol consumption causally affects the risk of developing both hyperuricemia and gout. The results indicate that genetically predicted drinks consumed per week have no causal effect on neither the risk of gout (p = 0.35), nor serum uric acid levels (p = 0.73). For MR analysis in the other direction, genetic risk of gout was significantly associated with drinks per week (p = 0.03). Furthermore, the results of the MR analysis were verified in a cohort of individuals diagnosed with hyperuricemi

SUBMITTER: Syed AAS 

PROVIDER: S-EPMC9028689 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature