3D-Printable Oxygen- and Drug-Carrying Nanocomposite Hydrogels for Enhanced Cell Viability.

ABSTRACT: Nanocomposite (NC) hydrogels have been widely studied due to their tunable biochemical/ physical properties for tissue engineering and biomedical applications. Nanoparticles (NPs) that can carry bioactive hydrophilic/hydrophobic molecules and provide sustained release within hydrogels are an ideal all-in-one-platform for local drug delivery applications. Dual delivery of different bioactive molecules is desired to achieve synergetic therapeutic effect in biomedical applications. For example, the co-administration of drug molecules and oxygen (O₂) is an ideal choice to improve cell viability, while reducing the harmful effects of hypoxia. Therefore, we prepared drug-loaded O₂-carrying periodic mesoporous organosilica (PMO-PFC) NPs and their 3D-printable hydrogel precur

SUBMITTER: Kumar R 

PROVIDER: S-EPMC9028881 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature