Double Repositioning: Veterinary Antiparasitic to Human Anticancer.

ABSTRACT: Drug repositioning, the approach of discovering different uses for existing drugs, has gained enormous popularity in recent years in the anticancer drug discovery field due to the increasing demand for anticancer drugs. Additionally, the repurposing of veterinary antiparasitic drugs for the treatment of cancer is gaining traction, as supported by existing literature. A prominent example is the proposal to implement the use of veterinary antiparasitics such as benzimidazole carbamates and halogenated salicylanilides as novel anticancer drugs. These agents have revealed pronounced anti-tumor activities and gained special attention for "double repositioning", as they are repurposed for different species and diseases simultaneously, acting via different mechanisms depending on their target. As

SUBMITTER: Sultana T 

PROVIDER: S-EPMC9029030 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature