The Effectiveness of Isoplumbagin and Plumbagin in Regulating Amplitude, Gating Kinetics, and Voltage-Dependent Hysteresis of erg-mediated K⁺ Currents.

ABSTRACT: Isoplumbagin (isoPLB, 5-hydroxy-3-methyl-1,4-naphthoquinone), a naturally occurring quinone, has been observed to exercise anti-inflammatory, antimicrobial, and antineoplastic activities. Notably, whether and how isoPLB, plumbagin (PLB), or other related compounds impact transmembrane ionic currents is not entirely clear. In this study, during GH₃-cell exposure to isoPLB, the peak and sustained components of an erg (ether-à-go-go related gene)-mediated K⁺ current (I_K(erg)) evoked with long-lasting-step hyperpolarization were concentration-dependently decreased, with a concomitant increase in the decaying time constant of the deactivating current. The presence of isoPLB led to a differential reduction in the peak and sustained components

SUBMITTER: Chen L 

PROVIDER: S-EPMC9029050 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature