Prostanoid Signaling in Cancers: Expression and Regulation Patterns of Enzymes and Receptors.

ABSTRACT: Cancer-associated disturbance of prostanoid signaling provides an aberrant accumulation of prostanoids. This signaling consists of 19 target genes, encoding metabolic enzymes and G-protein-coupled receptors, and prostanoids (prostacyclin, thromboxane, and prostaglandins E₂, F_2α, D₂, H₂). The study addresses the systems biology analysis of target genes in 24 solid tumors using a data mining pipeline. We analyzed differential expression patterns of genes and proteins, promoter methylation status as well as tissue-specific master regulators and microRNAs. Tumor types were clustered into several groups according to gene expression patterns. Target genes were characterized as low mutated in tumors, with the exception of melanoma. We found at least six

SUBMITTER: Ershov PV 

PROVIDER: S-EPMC9029281 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature