Chromatin Structure and Dynamics: Focus on Neuronal Differentiation and Pathological Implication.

ABSTRACT: Chromatin structure is an essential regulator of gene expression. Its state of compaction contributes to the regulation of genetic programs, in particular during differentiation. Epigenetic processes, which include post-translational modifications of histones, DNA methylation and implication of non-coding RNA, are powerful regulators of gene expression. Neurogenesis and neuronal differentiation are spatio-temporally regulated events that allow the formation of the central nervous system components. Here, we review the chromatin structure and post-translational histone modifications associated with neuronal differentiation. Studying the impact of histone modifications on neuronal differentiation improves our understanding of the pathophysiological mechanisms of chromatinopathies and opens u

SUBMITTER: Nothof SA 

PROVIDER: S-EPMC9029427 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature