Human Calicivirus Typing tool: A web-based tool for genotyping human norovirus and sapovirus sequences.

ABSTRACT:

Background

The family Caliciviridae consists of a genetically diverse group of RNA viruses that infect a wide range of host species including noroviruses and sapoviruses which cause acute gastroenteritis in humans. Typing of these viruses relies on sequence-based approaches, and therefore there is a need for rapid and accurate web-based typing tools.

Objective

To develop and evaluate a web-based tool for rapid and accurate genotyping of noroviruses and sapoviruses.

Methods

The Human Calicivirus Typing (HuCaT) tool uses a set of curated reference sequences that are compared to query sequences using a k-mer (DNA substring) based algorithm. Outputs include alignments and phylogenetic trees of the 12 top matching reference sequences for each query.

Results

The HuCa

SUBMITTER: Tatusov RL 

PROVIDER: S-EPMC9029540 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature