Metal ion size profoundly affects H₃glyox chelate chemistry.

ABSTRACT: The bisoxine hexadentate chelating ligand, H₃glyox was investigated for its affinity for Mn²⁺, Cu²⁺ and Lu³⁺ ions; all three metal ions are relevant with applications in nuclear medicine and medicinal inorganic chemistry. The aqueous coordination chemistry and thermodynamic stability of all three metal complexes were thoroughly investigated by detailed DFT structure calculations and stability constant determination, by employing UV in-batch spectrophotometric titrations, giving pM values (pM = -log[M ⁿ⁺]_free when [M ⁿ⁺] = 1 μM, [L] = 10 μM at pH 7.4 and 25 °C) - pCu (25.2) > pLu (18.1) > pMn (12.0). DFT calculated structures revealed different geometries and coordination preferences of the three meta

SUBMITTER: Choudhary N 

PROVIDER: S-EPMC9029555 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature