DNMT3B System Dysregulation Contributes to the Hypomethylated State in Ischaemic Human Hearts.

ABSTRACT: A controversial understanding of the state of the DNA methylation machinery exists in ischaemic cardiomyopathy (ICM). Moreover, its relationship to other epigenetic alterations is incomplete. Therefore, we carried out an in-depth study of the DNA methylation process in human cardiac tissue. We showed a dysregulation of the DNA methylation machinery accordingly with the genome-wide hypomethylation that we observed: specifically, an overexpression of main genes involved in the elimination of methyl groups (TET1, SMUG1), and underexpression of molecules implicated in the maintenance of methylation (MBD2, UHRF1). By contrast, we found DNMT3B upregulation, a key molecule in the addition of methyl residues in DNA, and an underexpression of miR-133a-3p, an inhib

SUBMITTER: Tarazon E 

PROVIDER: S-EPMC9029641 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature