Therapeutic Vaccines Targeting Neoantigens to Induce T-Cell Immunity against Cancers.

ABSTRACT: Cancer immunotherapy has achieved multiple clinical benefits and has become an indispensable component of cancer treatment. Targeting tumor-specific antigens, also known as neoantigens, plays a crucial role in cancer immunotherapy. T cells of adaptive immunity that recognize neoantigens, but do not induce unwanted off-target effects, have demonstrated high efficacy and low side effects in cancer immunotherapy. Tumor neoantigens derived from accumulated genetic instability can be characterized using emerging technologies, such as high-throughput sequencing, bioinformatics, predictive algorithms, mass-spectrometry analyses, and immunogenicity validation. Neoepitopes with a higher affinity for major histocompatibility complexes can be identified and further applied to the field of cancer vacc

SUBMITTER: Pao SC 

PROVIDER: S-EPMC9029780 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature