Supplementation with the Symbiotic Formulation Prodefen^® Increases Neuronal Nitric Oxide Synthase and Decreases Oxidative Stress in Superior Mesenteric Artery from Spontaneously Hypertensive Rats.

ABSTRACT: In recent years, gut dysbiosis has been related to some peripheral vascular alterations linked to hypertension. In this work, we explore whether gut dysbiosis is related to vascular innervation dysfunction and altered nitric oxide (NO) production in the superior mesenteric artery, one of the main vascular beds involved in peripheral vascular resistance. For this purpose, we used spontaneously hypertensive rats, either treated or not with the commercial synbiotic formulation Prodefen^® (10⁸ colony forming units/day, 4 weeks). Prodefen^® diminished systolic blood pressure and serum endotoxin, as well as the vasoconstriction elicited by electrical field stimulation (EFS), and enhanced acetic and butyric acid in fecal samples, and the vasodilation induced by the

SUBMITTER: Mendez-Albinana P 

PROVIDER: S-EPMC9029967 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature