Restricting Branched-Chain Amino Acids within a High-Fat Diet Prevents Obesity.

ABSTRACT: Obesity is a global pandemic, but there is yet no effective measure to control it. Recent metabolomics studies have identified a signature of altered amino acid profiles to be associated with obesity, but it is unclear whether these findings have actionable clinical potential. The aims of this study were to reveal the metabolic alterations of obesity and to explore potential strategies to mitigate obesity. We performed targeted metabolomic profiling of the plasma/serum samples collected from six independent cohorts and conducted an individual data meta-analysis of metabolomics for body mass index (BMI) and obesity. Based on the findings, we hypothesized that restriction of branched-chain amino acids (BCAAs), phenylalanine, or tryptophan may prevent obesity and tested our hypothesis in a di

SUBMITTER: Liu M 

PROVIDER: S-EPMC9030079 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature