Association of Androgenic Regulation and MicroRNAs in Acinar Adenocarcinoma of Prostate.

ABSTRACT:

Background

Prostate cancer represents 3.8% of cancer deaths worldwide. For most prostate cancer cells to grow, androgens need to bind to a cellular protein called the androgen receptor (AR). This study aims to demonstrate the expression of five microRNAs (miRs) and its influence on the AR formation in patients from the northern region of Brazil.

Material and methods

Eighty-four tissue samples were investigated, including nodular prostatic hyperplasia (NPH) and acinar prostatic adenocarcinoma (CaP). Five miRs (27a-3p, 124, 130a, 488-3p, and 506) were quantified using the TaqMan^® Real Time PCR method and AR was measured using Western blotting.

Results

Levels of miRs 124, 130a, 488-3p, and 506 were higher in NPH samples. Conversely, in the CaP cases, higher le

SUBMITTER: Bernardes JGB 

PROVIDER: S-EPMC9030213 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature