Global Evolutionary History and Dynamics of Dengue Viruses Inferred from Whole Genome Sequences.

ABSTRACT: Dengue is an arboviral disease caused by dengue virus (DENV), leading to approximately 25,000 deaths/year and with over 40% of the world's population at risk. Increased international travel and trade, poorly regulated urban expansion, and warming global temperatures have expanded the geographic range and incidence of the virus in recent decades. This study used phylogenetic and selection pressure analyses to investigate trends in DENV evolution, using whole genome coding sequences from publicly available databases alongside newly sequenced isolates collected between 1963-1997 from Southeast Asia and the Pacific. Results revealed very similar phylogenetic relationships when using the envelope gene and the whole genome coding sequences. Although DENV evolution is predominantly driven by nega

SUBMITTER: Stica CJ 

PROVIDER: S-EPMC9030598 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature