Blood Plasma Stabilized Gold Nanoclusters for Personalized Tumor Theranostics.

ABSTRACT: Personalized cancer theranostics has a potential to increase efficiency of early cancer diagnostics and treatment, and to reduce negative side-effects. Protein-stabilized gold nanoclusters may serve as theranostic agents. To make gold nanoclusters personalized and highly biocompatible, the clusters were stabilized with human plasma proteins. Optical properties of synthesized nanoclusters were investigated spectroscopically, and possible biomedical application was evaluated using standard cell biology methods. The spectroscopic investigations of human plasma proteins stabilized gold nanoclusters revealed that a wide photoluminescence band in the optical tissue window is suitable for cancer diagnostics. High-capacity generation of singlet oxygen and other reactive oxygen species was also obs

SUBMITTER: Jarockyte G 

PROVIDER: S-EPMC9030650 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature