Unknown

Dataset Information

0

Phycocyanin Ameliorates Colitis-Associated Colorectal Cancer by Regulating the Gut Microbiota and the IL-17 Signaling Pathway.

ABSTRACT: Phycocyanin (PC) is a pigment-protein complex. It has been reported that PC exerts anti-colorectal cancer activities, although the underlying mechanism has not been fully elucidated. In the present study, azoxymethane (AOM)/dextran sulfate sodium (DSS)-induced mice were orally administrated with PC, followed by microbiota and transcriptomic analyses to investigate the effects of PC on colitis-associated cancer (CAC). Our results indicated that PC ameliorated AOM/DSS induced inflammation. PC treatment significantly reduced the number of colorectal tumors and inhibited proliferation of epithelial cell in CAC mice. Moreover, PC reduced the relative abundance of Firmicutes, Deferribacteres, Proteobacteria and Epsilonbacteraeota at phylum level. Transcriptomic analysis showed that the expression of genes involved in the intestinal barrier were altered upon PC administration, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis revealed the IL-17 signaling pathway was affected by PC treatment. The study demonstrated the protective therapeutic action of PC on CAC.

SUBMITTER: Pan D 

PROVIDER: S-EPMC9030732 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Phycocyanin Ameliorates Colitis-Associated Colorectal Cancer by Regulating the Gut Microbiota and the IL-17 Signaling Pathway.

Pan Dongjin D   Huang Bingyao B   Gan Yuman Y   Gao Chenghai C   Liu Yonghong Y   Tang Zhenzhou Z  

Marine drugs 20220409 4

Phycocyanin (PC) is a pigment-protein complex. It has been reported that PC exerts anti-colorectal cancer activities, although the underlying mechanism has not been fully elucidated. In the present study, azoxymethane (AOM)/dextran sulfate sodium (DSS)-induced mice were orally administrated with PC, followed by microbiota and transcriptomic analyses to investigate the effects of PC on colitis-associated cancer (CAC). Our results indicated that PC ameliorated AOM/DSS induced inflammation. PC trea  ...[more]

Similar Datasets

Unknown Korean Traditional Medicine (Jakyakgamcho-tang) Ameliorates Colitis by Regulating Gut Microbiota.
| S-EPMC6835967 | biostudies-literature
Unknown Kui Jie Tong Ameliorates Ulcerative Colitis by Regulating Gut Microbiota and NLRP3/Caspase-1 Classical Pyroptosis Signaling Pathway.
| S-EPMC9273439 | biostudies-literature
Unknown VEGF-C mediated enhancement of lymphatic drainage reduces intestinal inflammation by regulating IL-9/IL-17 balance and improving gut microbiota in experimental chronic colitis.
| S-EPMC5714765 | biostudies-literature
Unknown Precision editing of the gut microbiota ameliorates colitis.
| S-EPMC5804340 | biostudies-literature
Unknown Tamarind Seed Polysaccharide Hydrolysate Ameliorates Dextran Sulfate Sodium-Induced Ulcerative Colitis via Regulating the Gut Microbiota.
| S-EPMC10459238 | biostudies-literature
Unknown <i>B. adolescentis</i> ameliorates chronic colitis by regulating Treg/Th2 response and gut microbiota remodeling.
| S-EPMC7889144 | biostudies-literature
Unknown Cassane diterpenoid ameliorates dextran sulfate sodium-induced experimental colitis by regulating gut microbiota and suppressing tryptophan metabolism.
| S-EPMC9893013 | biostudies-literature
Unknown Chang qing formula ameliorates colitis-associated colorectal cancer <i>via</i> suppressing IL-17/NF-κB/STAT3 pathway in mice as revealed by network pharmacology study.
| S-EPMC9382085 | biostudies-literature
Unknown Acacetin Ameliorates Experimental Colitis in Mice via Inhibiting Macrophage Inflammatory Response and Regulating the Composition of Gut Microbiota.
| S-EPMC7848181 | biostudies-literature
Unknown <i>Rosa Roxburghii</i> Tratt Fruit Extract Prevents Dss-Induced Ulcerative Colitis in Mice by Modulating the Gut Microbiota and the IL-17 Signaling Pathway.
| S-EPMC10650662 | biostudies-literature