The Calcium Channel Subunit Gamma-4 as a Novel Regulator of MafA in Pancreatic Beta-Cell Controls Glucose Homeostasis.

ABSTRACT: Impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) are high-risk factors of diabetes development and may be caused by defective insulin secretion in pancreatic beta-cells. Glucose-stimulated insulin secretion is mediated by voltage-gated Ca²⁺ (Ca_V) channels in which the gamma-4 subunit (Ca_Vγ4) is required for the beta-cell to maintain its differentiated state. We here aim to explore the involvement of Ca_Vγ4 in controlling glucose homeostasis by employing the Ca_Vγ4^-/- mice to study in vivo glucose-metabolism-related phenotypes and glucose-stimulated insulin secretion, and to investigate the underlying mechanisms. We show that Ca_Vγ4^-/- mice exhibit perturbed glucose homeosta

SUBMITTER: Wu R 

PROVIDER: S-EPMC9030882 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature