Development of Dibenzothiazepine Derivatives as Multifunctional Compounds for Neuropathic Pain.

ABSTRACT: Neuropathic pain is a chronic and sometimes intractable condition caused by lesions or diseases of the somatosensory nervous system. Many drugs are available but unfortunately do not provide satisfactory effects in patients, producing limited analgesia and undesirable side effects. Thus, there is an urgent need to develop new pharmaceutical agents to treat neuropathic pain. To date, highly specific agents that modulate a single target, such as receptors or ion channels, never progress to the clinic, which may reflect the diverse etiologies of neuropathic pain seen in the human patient population. Therefore, the development of multifunctional compounds exhibiting two or more pharmacological activities is an attractive strategy for addressing unmet medical needs for the treatment of neuropat

SUBMITTER: Jung YH 

PROVIDER: S-EPMC9030932 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature