Incomplete Recovery of Zebrafish Retina Following Cryoinjury.

ABSTRACT: Zebrafish show an extraordinary potential for regeneration in several organs from fins to central nervous system. Most impressively, the outcome of an injury results in a near perfect regeneration and a full functional recovery. Indeed, among the various injury paradigms previously tested in the field of zebrafish retina regeneration, a perfect layered structure is observed after one month of recovery in most of the reported cases. In this study, we applied cryoinjury to the zebrafish eye. We show that retina exposed to this treatment for one second undergoes an acute damage affecting all retinal cell types, followed by a phase of limited tissue remodeling and regrowth. Surprisingly, zebrafish developed a persistent retinal dysplasia observable through 300 days post-injury. There is no ind

SUBMITTER: Dzulova D 

PROVIDER: S-EPMC9030934 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature