Blockade of TASK-1 Channel Improves the Efficacy of Levetiracetam in Chronically Epileptic Rats.

ABSTRACT: Tandem of P domains in a weak inwardly rectifying K⁺ channel (TWIK)-related acid sensitive K⁺-1 channel (TASK-1) is an outwardly rectifying K⁺ channel that acts in response to extracellular pH. TASK-1 is upregulated in the astrocytes (particularly in the CA1 region) of the hippocampi of patients with temporal lobe epilepsy and chronically epilepsy rats. Since levetiracetam (LEV) is an effective inhibitor for carbonic anhydrase, which has a pivotal role in buffering of extracellular pH, it is likely that the anti-epileptic action of LEV may be relevant to TASK-1 inhibition, which remains to be elusive. In the present study, we found that LEV diminished the upregulated TASK-1 expression in the CA1 astrocytes of responders (whose seizure activities were respon

SUBMITTER: Kim JE 

PROVIDER: S-EPMC9030960 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature