The Scaffold Protein PICK1 as a Target in Chronic Pain.

ABSTRACT: Well-tolerated and effective drugs for treating chronic pain conditions are urgently needed. Most chronic pain patients are not effectively relieved from their pain and suffer from debilitating drug side effects. This has not only drastic negative consequences for the patients' quality of life, but also constitute an enormous burden on society. It is therefore of great interest to explore new potent targets for effective pain treatment with fewer side effects and without addiction liability. A critical component of chronic pain conditions is central sensitization, which involves the reorganization and strengthening of synaptic transmission within nociceptive pathways. Such changes are considered as maladaptive and depend on changes in the surface expression and signaling of AMPA-type gluta

SUBMITTER: Sorensen AT 

PROVIDER: S-EPMC9031029 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature