Population Pharmacokinetics of Valproic Acid in Pediatric and Adult Caucasian Patients.

ABSTRACT: (1) Background: The aim of this study was to explore the valproic acid (VPA) pharmacokinetic characteristics in a large population of pediatric and adult Caucasian patients and to establish a robust population pharmacokinetic (PopPK) model. (2) Methods: A total of 2527 serum VPA samples collected from 1204 patients included in a therapeutic drug monitoring program were retrospectively analyzed. Patients were randomly assigned to either a model development group or an external evaluation group. PopPK analysis was performed on 1751 samples from 776 patients with NONMEM using a nonlinear mixed-effect modelling approach. The influence of demographic, anthropometric, treatment and comedication variables on the apparent clearance (CL/F) of VPA was studied. The bootstrap method was used to evalua

SUBMITTER: Teixeira-da-Silva P 

PROVIDER: S-EPMC9031051 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature