Three-Component Ni-Catalyzed Silylacylation of Alkenes.

ABSTRACT: A Ni-catalyzed silylacylation of alkenes is presented. The reaction combines alkenes, ClZnSiR₃, and acid chlorides to provide rapid access to β-silyl ketones. Importantly, the method involves a [Ni]-SiR₃ complex as a catalytic intermediate, which is rarely described for three-component alkene functionalization. Finally, the synthetic utility of the products is demonstrated, and the mechanistic details are described.

SUBMITTER: Ni D 

PROVIDER: S-EPMC9031101 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature